400 Quintillion Strains and Variants of Covid-19 Virus

By  Dr. Lim Ju Boo 

17/02/2021 @ 8:19 AM

Over this lazy afternoon today I was wondering if scientists have all along got their directions wrong by producing all sort of vaccines, without considering the various ways the sequence of the RNA of SARS-CoV-2 could arrange themselves to give rise to various mutagenic strains and variants which may render all existing vaccines to be useless.          

 

For instance, the Oxford-AstraZeneca vaccine has now been found to offer limited protection against the mutant South Africa variant of Covid-19 virus based on about 2,000 young people who had the vaccine.

 

I was looking at the various permutations and combinations their sequence could arrange themselves into various sub-sets of genomes and their capability of mutating in appalling ways and numbers we fail to even dream.  

 

I like to share my thoughts on this dilemma mathematically rather than biologically other scientists have been focusing on all this while.   

We know the nucleotides that comprise the RNA of the virus contain a nitrogenous base, a deoxyribose sugar, and a phosphate group which covalently link with other nucleotides to form phosphodiester bonds.

 

Nucleotides are the monomers that make up a nucleic acid, such as DNA or RNA. Nucleic acids are made of long strands of nucleotides. 

 

A nucleic acid sequence is a succession of bases signified by a series of a set of five different letters that indicate the order of nucleotides forming alleles within a DNA.

 

In short its nucleotides may have just three groups, but their individual group arrangements into nucleic acids through combination and permutation can run into millions of billions of codes.

 

The corona viruses of Covid-19 have single-stranded, positive-sense genomes that are the largest of all known RNA viruses. Its nucleotide chain is between 27 – 32 kilo base (Masters, 2006).

 

The genome of this Covid-19 is about 30,000 characters long. In short it has a 5 digit code, all are capable of rearranging the sequence to cause them to mutate into unthinkable numbers.

 

Epidemiologists estimated the genomic mutation rate of SARS-CoV-2 viruses at 33 per year. Scientists use the presence of these mutations in SARS-CoV-2 genomes to assign a lineage or clade to each strain.

 

But I think initially its mutation rate can be extremely slow, but this may be a deadly misjudgment and a lethal mistake we are going to pay pricey if we intend to challenge this virus with a fight using all sorts of vaccines.

 

As far as I can foresee, we are not fighting with a virus, but we are raging a war against an Intelligent Designer who has put this virus here on this planet with an intended purpose.  

 

The Combination and Permutations of Mutations:

 

The number of permutations possible for the SARS-CoV-2 to change the order of their sequence, assuming just a small fraction of 30 nucleotides were taken from its genetic code (the sequence of nucleotides in the ribonucleic acid (RNA) that determines the amino acid sequence of the spike proteins) would be, assuming r = 10 of them were taken at a time. 

 

This would be:

 

n P r = n! / (n – r)! = 30! / (30 – 10)! = 1 x 1014   = 100 trillion

 

However I do not think this would normally be the case, because as far as we know from our knowledge on genetics, cellular and molecular biology, mutation is normally randomly-assigned without considering the order of the arrangement of their sequence.

 

The sequence during mutation most likely is randomized rather than chosen in a specific order. In other words, mutation is normally a random change in its sequence.

 

We would then have to look at this problem in another way if the sequence of their nucleotides is randomly arranged without any concern of order.

 

Put this in another way, we would have to look at how the sequence are combined which is more likely rather than permuted in a fixed arrangement.

 

Such randomly-assigned combinations would give rise to far more numbers of mutations, and subsequent strains and variants rather than through more through prescribed permutations.

 

Mathematically we will then apply a different equation for this biological threat to mankind given as:

 

nCr  = n! / (n – r)! . r!

= 30! / 20! x 10! = 4 x 10 20 = 4 followed by 20 zeros or 400 quintillion

(1 quintillion = 1 followed by 18 zeros)

(30!, 20! or 10! are all factorials. For instance 10! or 10 factorial is equal to 10x 9x 8x 7x 6x 5x 4x 3x 2x 1x = 3628800).

(We assume conservatively when we took only 30 nucleotides of this SARS-Covid 2 genome which may more likely to be the genetic code, or just 0.1 % of the genome, and were rearranged with 10 codes taken at a time.)

          

If we assume this is more likely the  possibility, then there is no vaccine we need to look for any further or any other preventive measure we need to enforce additionally against the capability of this virus to mutate randomly to a tune a 100 quintillion different variants.

 

400 Quintillion Types of Vaccines vs. A 400 Quintillions Mutagenic Variants? 

If this virus uses just 0.1 % of sequence to rearrange themselves to a 400 quintillion different mutagenic combinations would scientists also wish to fight and match them with a 400 quintillion various types of vaccines?  Yes, or No? Just answer my question.

Furthermore, it is projected there will be 8.5 thousand million people on this planet by the year 2030 which is another 9 years time in the Year of the Dog (A dog’s life by then).

 

This means if this virus mutates to its theoretical limit, though it may not be likely through the Grace of God, then each individual on this planet in about 10 years time will need to receive at least 4.7 x 1010, that’s 47,000,000,000 different types of vaccines to cope with the flood of mutations this virus is capable of transforming itself by merely rearranging 0.1 % of its sequence.

My personal feeling towards this predicament it is best we lay down all our biological arms – vaccines, drugs and anything other thing we can think of, and just ask for forgiveness from our Creator for trying to fight with Him as it is already clearly written that a third of the population of the earth would be killed by four angels and the army which they lead (Revelation 9:16-18).

 

This is an unyielding divine decree that must come to pass periodically to cut down overpopulation according to the prescribed laws of Natural Selection for the survival of the fittest and to get rid of the old and infirmed, those with comorbidities, those who are immunologically compromised or those genetically malformed as we can see from the nature of the mortality from this pandemic.

 

If we look at this again, it is not just the horrendously huge numbers of mutant variants this virus is capable if we attempt to challenge them with various types of vaccines, but it is their sheers numbers too that can rain down on this Earth.

 

This we may also need to consider here:

https://scientificlogic.blogspot.com/2021/02/our-vaccines-against-alien-invaders.html

 

Readers may also go into other general articles by Ir. Lau TO blog here:

https://taionn.blogspot.com/search?q=laU+TO

 

For other articles by this author (Lim Ju Boo) are found here:

https://taionn.blogspot.com/search?q=articles+by+Dr+Lim+

 

JB                             

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A further remark by Dr. Lim via WhatsApp on 17/02/2021 at 7.53pm:

As I have already explained earlier, this virus is not going to stop mutating into myriads of tens of thousands, or even into tens of thousands of trillions and there is no reason why it should not, all the more when we try to defy it with our vaccines and even natural antibodies.

If only scientists study evolutionary biology other than just virology and immunology and how to make vaccines, they will know why Nature has over 3 billion years of life on Earth helps every organism including prelife viruses to thrive against all environmental, physical and biological odds and challenges through the Law of Natural Selection.

 

Let this be known to every scientist trying to block this virus with their man-made vaccine, the more they try the more aggressive and mutant this virus is going to face us.

 

Don't think we are going to win this very tough biological war implanted here with a intended purpose to wipe out one third of the world population.

 

Seek His wisdom why, not rely on our idiotic scientific knowledge.  I mean it.

 

Jb 

 

https://www.businessinsider.com/virus-variant-in-11-countries-and-may-resist-antibodies-report-2021-2