Sunday, April 12, 2020

Natural Therapy for Coronavirus Infection and Prevention by Dr. JB Lim

How to keep yourself safe from new coronavirus? - Chinadaily.com.cnNote: The blogger is further requested by Dr. JB Lim to publish the following write-up by him.

These treatment suggestions for corona virus infection are in part reply to Prof Dr. Sen Gupta questions to me.

Steam Inhalation: Diseases and Conditions | Pediatric OncallI would like to suggest using steam inhalation + cod liver oil (retinol or vitamin A) + several pro-vitamin A carotenoids (most notably beta-carotene) + high doses of vitamin C at 500 mg tds (500 mg three times a day = 1,500 mg) at 8 hour interval. 

A vegan or vegetarian diet rich beta carotene is -  carrots, yellow or orange sweet potatoes, dark leafy green vegetables,  spinach, red and yellow peppers, and fruits such as papaya and mangoes. Hence a diet rich in fruits and vegetables is very infection-protective.  

There are some evidences that high doses of vitamin C can be used to treat cases of coronavirus infection here:


Phagocytosis Images, Stock Photos & Vectors | ShutterstockIt has been shown that vitamin C plays a role in the defence mechanisms against microbial invasion by increasing the number and function of phagocytic cells and their phagocytosis.

The pathway taken is through the generation of reactive oxygen free radicals against the bacteria and also by increasing the chemotaxis of neutrophil granulocytes.

Chemotaxis | Signaling Pathway in Bacteria - YouTubeChemotaxis is the movement of an organism such as lymphocytes in the white blood corpuscles in response to a chemical or clinical pathology.

It probably works in the same way for a virus infection by mobilizing the plasma B and T cells of the lymphocytes by generating different components of antibodies (immunoglobulin IgA, IgE, IgM) against viruses including SARS CoV and Covid-19.

The findings and reasons are the same as what double-winner Linus Carl Pauling advocated using  mega doses of vitamin C in treating and preventing a cold caused by almost the same type of nasal and respiratory viruses such as rhinovirus, coronavirus, RSV and para-influenza viruses and Covid-19 virus. 

However hospitals use intravenous injections of the same dose of vitamin C for rapid infusion.

Vitamin c in food Royalty Free Vector Image - VectorStockVitamin C Kinetic:

However, in my professional opinion this is unnecessary because vitamin C nutri-kinetics of absorption, distribution, retention time and excretion into the urine is very rapid - within just 4 hours after blood saturation. 

Hence logically it does not make sense to me to infuse vitamin C via IV for rapid blood saturation because this will proportionally decrease the retention time and accelerate the time of excretion.

What is more important and troublesome especially with the current pandemic  of coronavirus and the lockdown in most countries, if IV is given, it has  to be done in a hospital, and this is the worse time to go to a hospital and get yourselves exposed. There is a very high risk factor if you go to a hospital. 

Hence I STRONGLY recommend that doses of vitamin C be given ORALLY at 8 hour interval as its kinetics of excretion is within 7 – 8 hours at this dose. 

Lower doses causes longer retention time due to a delay in tissue absorption from the blood whereas higher doses than 500 mg tds causes a very rapid loss into the urine.

My very strong recommendation is that vitamin at this doses is to be taken  ORALLY in the comfort of our home  (NOT go to a hospital for IV bolus infusion) .

Vitamin A rich foods for skinVitamin A:

Next, 5 ml (teaspoonful) of cod liver oil three times a day is an adjunct treatment or prophylaxis against respiratory infections.  

DO NOT exceed this dose, else there may be a risk of hypervitaminosis A and liver damage. 

The rational and pharmacodynamics (mode of action) of vitamin A is to increase the bronchial ciliary sweep in the airways to remove  any virus trapped  in the bronchial tubes so that they can be swept upwards into larynx and from there swallowed down the oesophagus into the digestive tract where proteolytic  (protein-digesting) enzymes will act on the protein-coat (capsid) of the coronavirus and destroy the virus instantly.

Mucus Clearance:

In short simple technical language, vitamin A in cod liver oil enhances mucus clearance and greatly reduces the virus load in the throat and respiratory airways. 

A decrease in the virus load will give time for the body to build up its immunoglobulin (IgA IgE, IgM…) against the virus.

Antibodies Response to Virus Load:

The lesser the virus-load the better it is. The infected person will remain symptom-free for much longer time until antibodies can be produced in response. 

Pneumonia and Coronavirus | Health PlusFever:

Similarly, if there is a fever do NOT suppress the fever with an antipyretic such as paracetamol.

The fever is there to STAY. The fever is there to fight an infection through many pathways. Do NOT suppress it to immobilize its pathogenic-fighting functions.

Cough:

Likewise, if you develop a cough, especially a productive cough with phlegm, do NOT suppress it. Cough it out together with the phlegm and the virus stuck on to the sticky mucus.

Cough  reflex  has a sound physiological function whereby the body tries to reduce the virus load or any pathogen or chemical irritant in the airways.

Hence, do NOT use cough medicines to block the cough especially antitussives that are cough suppressants. They relieve your cough by blocking the cough reflex. Expectorants maybe used as they thins the mucus, but even that is not advisable

It is much better to use physical therapy such as steam inhalation. The reasons are found in this blog

See blog on Steam Inhalation here:

Hope these  suggestions in Natural Medicine help

lim ju boo
BSc PG Dip Nutri MSc MD PhD FRSPH FRSM
Post-doctoral CE in
Evolution (University of Cambridge)
Astronomy (University of Oxford)
Forensic Science: Toxicology (University of Cambridge)

Prevention vs. Treatment in Anderson | Dr. Hardy and Dr. WilsonFurther reading from Dr. JB Lim’s blog:
Natural Treatment for Corona Virus Infection or Prevention

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Thursday, April 09, 2020

Dr. JB Lim On Tests For Covid-19

Five Lessons From The Coronavirus | Pinchas Allouche | The BlogsNote: The blogger is given the privilege by the Great Sifu Dr. Lim Ju Boo to post inside this blog his responses to Tan Sri Prof. Gupta’s questions on the recommended test and treatment of Coronavirus that is current raging the world.

WhatsApp Tue. Apri 7, 09:00 PM:

Dear Prof Dr Lim Ju Boo,

Can you advise us which is the best test to do for Covid-19 and what treatment can we use to protect ourselves for this terrible pandemic infection?

You are the only person whom we trust and greatly respect with your vast, vast knowledge in everything!

Thank you.

Gupta

Email Wed, Apr 8, 11:36 PM from Dr. JB Lim:

Dear Prof Tan Sri Gupta,

Thank you for your two very difficult and challenging questions to floor me down.

First of all I do now know many things, and I am unsure how to answer your requests

I can only try my level best.

Pertaining to your first question which is the best test to use for detecting corona virus infection depends on what we are looking for.

1. Are we looking for the presence of the virus, meaning the specific protein called the surface antigen found on the coat of the virus and subsequently in the throat of a person of an infected person, but has not developed the disease or the symptoms yet?

Or,

2. Are we looking for the antibodies produced by the person already infected and has the disease?

Sensitivity and specificity: Video & Anatomy | OsmosisFor both 1 & 2 above, it depends on what we call “specificity” and “sensitivity” which is again subject to the method used, such as using the (rapid) diagnostic kits.

Some tests are very specific for that antigen (protein) expressed, example by this SPECIFIC and particular corona virus (covid-19).

Then we have to look at how sensitive a particular test we are going to use.

For instance, if a person has just a small amount of the virus stuck in his throat, or if the examiner did not do a throughout swab on his or her throat, then he is going to pick up very minute quantities of this antigen (corona virus).

Hence we can confidently say even if a particular antigen test is very specific, yet it is NOT sensitive enough to detect such a minute amount of the virus on his throat.

In short, it depends on the methodology, how the examiner takes the throat swab and how much virus load there is in his throat or even down his airways.

ELISA (enzyme-linked immunosorbent assay) - Bioscience NotesAlmost all of these tests are plate-based assay called “enzyme-linked immunosorbent assay” or ELISA which I mentioned many times before in this chat group.

This antigen detection test depends on a colour change on the wells of the plates, and this takes only a few seconds to read. That is why this test is called rapid test using commercially-prepared kits.

However I need to warn everyone if the test results come out negative because it is neither specific nor sensitive, you can give a person tested a sense of false security.

Reverse Transcription Polymerase Chain Reaction Images, Stock ...The best and most reliable test is by using the reverse transcription polymerase chain reaction (RT-PCR) which is a technique combining reverse transcription of RNA into DNA, sometimes called complementary DNA (Cdna) and amplifying the presence of specific DNA targets (virus) using polymerase chain reaction (PCR)..

But RT-PCR is a very advanced and sophisticated analysis that can only be performed, read and interpreted by a qualified medical diagnostic scientist working in a an advance research laboratory.

Not any Dick, Tom and Harry medical technician or a doctor can perform this analysis, and this may take days.

Coronavirus antibody test: what is it and how does it work? - AS.comThe second type of test that can be done is, instead of trying to detect for the antigen (virus) in the throat, is to look for antibodies already acquired by a person who is already ill with this virus or who has already been infected for many days but remains “healthy” and presented asymptomatically (no symptoms).

In this case, instead of a throat swab, a drop of blood from finger prick will do.

What we do is to look for antibodies (Immunoglobulin ((IgA, IgG, IgM, IgD…etc) elicited by the body in response to the infection.

But which fraction or sub-class fraction of these immunoglobulin is specific to this class of Coronavirus (Covid-19) I am not too sure, because any type of infections including bacterial will elicit any of these antibodies.

Again we are back to two problems on specificity and sensitivity..

In the case of sensitivity for antibodies for Coronavirus, we have to look at the duration since infection as it takes time for the body to produce the antibodies for them to rise for detection.

If the infection is mild or only just started a few days ago, we may not be able to pick it up.

In short, the amount of antibodies stimulated may not be in sufficient amount to be detected, thus giving a false negative.

Coronavirus Symptoms, Diagnosis, Treatment, & Vaccine Status ...Diagnosis of corona virus infection is very challenging and difficult at this moment in time for clinicians and medical scientists because it is so new.

Until we have better understanding and data, these two diagnostic approaches serves us well.

Least of all, we should not depend on symptoms like fever and coughs alone. Symptoms are only guidelines, not conclusive.

Sorry you have asked me these two very difficult questions for which I have no practical experience.

This is my academic level best in answering. I hope it helps

What is the Oort Cloud?As to your other question on the best approach in treatment or on how to enhance our body’s immunity to this disease, can I answer that later because actually I am in this midst of doing some astronomical calculations on the size of Earth, Oort Cloud and the comparative dimensions to the edge of an Observable Universe, and their relationship to whether or not life cloud exists in other worlds – something that interests me far more than Coronavirus or medicine.

Eyes In The Skies: Bringing the Universe Down To Earth | World ...In fact, I am now having a headache calculating and re-calculating the astronomical data for hours now to ensure scientific accuracy.

So give me time for astronomical mathematics instead of suggesting some “cure” for this terrible infection that has claimed the lives of hundreds of thousands of people world-wide.

Kindly be patient. Let me think carefully first.

Thank you for your questions

Lim ju boo

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